Protein Science - Research Outputs - Lund University

Protein Science - Research Outputs - Lund University

Small heat shock proteins (sHsps) have multiple cellular functions. However, the biological function of sHsps in pathogenic microorganisms is largely unknown. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans. Using a reverse genetics approach we demonstrate the importance of Hsp21 for resistance of C. albicans to specific Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans François L Mayer, Duncan Wilson, Ilse D Jacobsen, Pedro Miramón, Silvia Slesiona, Iryna M Bohovych, Alistair J P Brown, Bernhard Hube Candida är en saprofytisk, opportunistisk jästsvamp.

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Small heat shock proteins (sHsps) have multiple cellular functions. However, the biological function of sHsps in pathogenic microorganisms is largely unknown. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans. Using a reverse genetics approach we demonstrate the importance of Hsp21 for resistance of C. albicans to specific Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans François L Mayer, Duncan Wilson, Ilse D Jacobsen, Pedro Miramón, Silvia Slesiona, Iryna M Bohovych, Alistair J P Brown, Bernhard Hube Candida är en saprofytisk, opportunistisk jästsvamp. Vid mikroskopi påvisas jästceller, med eller utan hyfer/pseudohyfer (flera hyfer benämns mycel).

Hsp21 is also found in other fungal pathogens such as Candida  Dissection of the Candida albicans lipase gene family and its role in Hube B ( 2013) Hsp21 potentiates antifungal drug tolerance in Candida albicans. 7 Jun 2012 In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans.

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Using a reverse genetics approach we demonstrate the importance of Hsp21 for resistance of C. albicans to specific stresses, including thermal and oxidative stress. • Candida spp are the fourth most common cause of hospital-acquired systemic infections in the United States with crude mortality rates of up to 50%.

Protein Science - Research Outputs - Lund University

Using a reverse genetics approach we demonstrate the importance of Hsp21 for Hsp21 potentiates antifungal drug tolerance in Candida albicans. Mayer F.L., Wilson D., Hube B. Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these infections is hampered by the relatively low number of available antifungal drugs. Although, Candida albicans (C. albicans) are one of the main etiologic agent for candidiasis, the small heat shock protein 21 (sHsp21) in C. albicans showed its pivotal role for environmental stress adaptation and fungal virulence. In C. albicans Hsp21 is a necessary factor for thermal and oxidative stress tolerance.

4. Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLoS One. 2012; 7(6):e38584 (ISSN: 1932-6203) Small but crucial : the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans By François L Mayer, Duncan Wilson, Ilse D Jacobsen, Pedro Miramón, Silvia Slesiona, Iryna M Bohovych, Alistair J P Brown and Bernhard Hube 31 Oct 2019 Candida albicans, a polymorphic opportunistic pathogen associated with ( through up-regulation of Lys7 and Hsp21 respectively) (Dong et al. The ability of the human pathogenic fungus Candida albicans to switch between HSP21, which encodes a small heat shock protein that is important for  31 Aug 2018 The human fungal pathogen Candida albicans possesses two genes Hsp21, - 70, -104, which have been shown to have roles in virulence  ‪‪Cited by 4337‬‬ - ‪fungal pathogens‬ - ‪Candida albicans‬ - ‪host pathogen‬ Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in Candida  Here, we first investigated the phenotypic characteristics of Candida biofilm persisters Several aforementioned highly expressed proteins (HSP21, RAS1, and  Duncan Wilson is a Wellcome Trust Senior Fellow. He discovered and characterised the first zinc scavenging mechanism of Candida albicans - the secreted  Miramón P, Kasper L, Hube B (2013) Thriving within the host: Candida spp.
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Heat shock protein required for pathogenicity.

HSP21 - Small heat shock protein 21 - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) - HSP21 gene & protein UniProtKB - Q5AHH4 (HSP21_CANAL) HSP21 orthologues are present in the majority of pathogenic Candida species, the gene is not found in humans. These results indicate that Hsp21 represents an attractive alternative to Hsp90 for combinatorial immunotherapeutic-antifungal treatment strat-egies. Results Phylogenetic relatedness of C. albicans Hsp21 and human sHsps Hsp21 was found in several pathogenic Candida species but not in humans. This prompted us to investigate the effects of a broad range of different antifungal drugs on an Hsp21-null C. hsp21 Small heat shock protein 21; Heat shock protein required for pathogenicity.
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Infektionsmedicin - Forskningsoutput - Lunds universitet

This prompted us to investigate the effects of a broad range of different antifungal drugs on an Hsp21-null C. HSP21: Small heat shock protein 21; Heat shock protein required for pathogenicity. Mediates thermotolerance and adaptation to oxidative stress and ethanol- induced stress. Required for invasive growth and filament formation under various filament inducing conditions. Se hela listan på folkhalsomyndigheten.se För klinik och behandlingsindikation vid svampinfektioner: Visa behandlingsöversikt: Svampinfektioner (invasiva), diagnostikBAKGRUND Invasiva svampinfektioner ökar i frekvens och drabbar främst patienter som: Är immunsupprimeradeGenomgår avancerad medicinsk behandling (dialys, antibiotikaterapi, intravenös nutrition)Genomgått stor kirurgiDe vanligaste svamppatogenerna utgörs av BAKGRUND Candidavaginit är vanligt hos kvinnor i fertil ålder och minst 75 % drabbas någon gång av en symtomgivande infektion.

Protein Science - Research Outputs - Lund University

Five potential sHSPs have already been identified in the intracellular parasite Toxoplasma gondii. Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLoS One. 2012; 7(6):e38584 (ISSN: 1932-6203) CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Small heat shock proteins (sHsps) have multiple cellular functions.

Required for invasive growth and filament formation under various filament inducing conditions. 2020-09-07 Small Heat Shock Protein; Role In Stress Response And Virulence; Fluconazole-downregulated; Induced In Cyr1 Or Ras1 Mutant; Stationary Phase Enriched Protein; Detected In Some, Not All, Biofilm Extracts; Spider Biofilm Induced Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans.