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Neoplastic Stem Cells Subject Areas on Research 4-Hydroperoxycyclophosphamide purging of breast cancer from the mononuclear cell fraction of bone marrow in patients receiving high-dose chemotherapy and autologous marrow support: a phase I trial. McLendon et al., "Glioma stem cells promote radioresistance by preferential activation of the DNA damage response," Nature, vol. The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer 2006-10-18 · The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

2006-12-01 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Author(s): Shideng Bao , Qiulian Wu , Roger E. McLendon , Yueling Hao , Qing Shi , Anita B. Hjelmeland , Mark W. Dewhirst , Darell D. Bigner , Jeremy N. Rich Glioma stem cells promote radioresistance by preferential activation of the DNA damage response 2021-03-09 · Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells3,4,5,6, is enriched after radiation in gliomas. cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour Notch inhibition with GSIs did not alter the DNA damage response of glioma stem cells following radiation, but rather impaired radiation-induced Akt activation and upregulated levels of the truncated apoptotic isoform of Mcl-1 (Mcl-1s). Taken together, our results suggest a critical role of Notch to promote radioresistance of glioma stem cells.

The fraction of tumour In response to radiation, cells activate the DNA damage response (DDR), which initiates a series of cascades involving cell cycle checkpoint activation, various forms of DNA repair and, if unsuccessful, inducing apoptosis.

Investigations of Proneural Glioblastoma to Identify - DiVA

Autores: Shideng Bao, Qing Shi, Yueling Hao, Roger E. McLendon, Darell D. Bigner, Qiulian Wu, Anita B. Hjelmeland, Jeremy N. Rich, Mark W. Dewhirst Add your e-mail address to receive free newsletters from SCIRP. In response to radiation, cells activate the DNA damage response (DDR), which initiates a series of cascades involving cell cycle checkpoint activation, various forms of DNA repair and, if unsuccessful, inducing apoptosis. GBMs are highly resistant to treatment for a number of reasons that will be discussed in more detail below. Finally, glioma cells expressing immature markers associated with stem cells and progenitors confer radioresistance and chemoresistance (15, 16), which is a typical feature in malignant gliomas.

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Download Citation | On Jan 1, 2008, R.J. Arceci published Glioma stem cells promote radioresistance by preferential activation of the DNA damage response | Find, read and cite all the research you The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage The blue social bookmark and publication sharing system. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. The fraction of tumour cells expressing CD133 (Prominin-1),… Cancer stem cells contribute to glioma radioresistance by an increase of DNA repair capacity through preferential activation of the DNA damage response checkpoints. Potential therapies that modulate or target cancer stem cells are also reviewed. 2006-12-01 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Author(s): Shideng Bao , Qiulian Wu , Roger E. McLendon , Yueling Hao , Qing Shi , Anita B. Hjelmeland , Mark W. Dewhirst , Darell D. Bigner , Jeremy N. Rich Glioma stem cells promote radioresistance by preferential activation of the DNA damage response 2021-03-09 · Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18. PMID 17051156 : Anaplastic oligodendroglioma.

The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease.
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Radioisotopes - Applications in Physical Sciences - Scribd

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature.

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Investigations of Proneural Glioblastoma to Identify - DiVA

2019-02-05 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp. 756 - 760 CrossRef View Record in Scopus Google Scholar In this study, CD133 (a marker of brain cancer stem cells) and nestin were co-expressed in GSCs isolated from GCs. The percent of CD133+ cells in GSCs and GCs were >80 and 2%, respectively. Significantly more GSCs survived following 2, 4, 6 and 8 Gy IR than GCs. IR kills cancer cells primarily through DNA double-strand breaks (DSBs).

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GBMs are highly resistant to treatment for a number of reasons that will be discussed in more detail below. Finally, glioma cells expressing immature markers associated with stem cells and progenitors confer radioresistance and chemoresistance (15, 16), which is a typical feature in malignant gliomas. These findings contrast to some extent those reported by Singh and colleagues, that glioma cells exhibiting proliferation and self-renewal were exclusively CD133 positive ( 3 , 17 ). Profiling of matched pre- and post-treatment glioblastoma specimens revealed altered homeostasis of select miRNAs in response to radiation. Radiation-induced EV export of miR-603 simultaneously promoted the CSC state and up-regulated DNA repair to promote acquired resistance. These effects were abolished by exogenous miR-603 expression, suggesting potential for clinical translation. 2019-02-05 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp.

2006;444(7120):756–60.